Sergio Aguero may return to action against Stoke
Sergio Aguero will resume training with Manchester City's first-team squad on Friday and could be involved against Stoke City the following day.
The 24-year-old Argentina striker has been out since injuring his knee in City's opening game of the season.
"We will try this morning with Sergio," Mancini said. "After we try, we will decide. He is getting better."
When asked if he could be involved at the Britannia Stadium on Saturday, the Italian added: "Maybe."
Fellow forward Mario Balotelli has been cleared to play if needed after undergoing laser eye surgery during the international break.
The Italian had had difficulty wearing his contact lenses after being affected by conjunctivitis.
Mancini said: "Mario is OK. Mario now sees everything."
England midfielder Gareth Barry is close to returning after overcoming the abdominal problem that kept him out of Euro 2012 but defender Micah Richards remains sidelined with an ankle injury.
"Gareth hasn't played any games for almost four months and he needs to build his fitness up," said Mancini.
"But he is training again and I don't see him being out for any longer than one month and, hopefully, maybe just a couple of weeks.
"Micah's injury is more serious and he could be out a little longer. But, having said that, with rest and the right treatment, we are hopeful he could be ready in about one month."